Cancer

What are three factors that affect breast cancer penetrance?

What are three factors that affect breast cancer penetrance? (Penetrance is defined as the likelihood of cancer when a cancer predisposing mutation is present).

Will award points to the person who answers the question most accurately. Thanks!

- Many family members with Hx. of Br. Ca.

- Few family members with Hx. of Br. Ca.

- Polymorphisms in certain otherwise ‘protective’genes

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